Similar to sound, the key parameters of ultrasound are wave amplitude and wave frequency measured in cycles per second or hertz hz. By using the combination of highintensity focused ultrasound hifu and imaging method, fus has the potential to ablate tumor lesions precisely. Clinical applications of highintensity focused ultrasound. At present, a clinical trial on mrghifu is being held at 2 research institutes in the province. Principles and results of highintensity focused ultrasound for. Highintensity focused ultrasound treatment of liver.
High intensity focused ultrasound offers new tumor. High intensity focused ultrasound procedure for prostate. Highintensity focused ultrasound therapy korean j radiol 94, august 2008 293 fig. Intensity focused ultrasound of the prostate smiths. First high intensity focused ultrasound system for prostate. Past, present, and future in neurosurgery article pdf available in neurosurgical focus 442. Highintensity focused ultrasound hifu is emerging as a new modality. Edap, based in lyon, france, now has fda clearance to bring to the u. High intensity focused ultrasound target at fat of mmdepth of penetration, heating up the fat tissue, combine with high energy and good penetration to resolve the fat, during the treatment, the triglyceride and fatty acid excrete by the process of metabolism, and the vessal and nurve will not be damaged.
A type of thermotherapy or thermoablation for the treatment of benign prostateic hyperplasia and still under study for the treatment of cancer. High intensity focused ultrasound hifu is widely used for the treatment of tumors of various nature, competing with both traditional surgical methods and other noninvasive technologies of bio. Highintensity focused ultrasound hifu is a promising noninvasive thermal ablation technique. High intensity focused ultrasound thyroid center of santa. Hifu is one of the few prostate cancer treatments that can be categorized as a minimally invasive, out. High intensity focused ultrasound revised april 2014 number. Recent advances in hifu have increased its popularity. High intensity focused ultrasound hifu for pancreatic carcinoma. Abstract background highintensity focused ultrasound hifu has been widely accepted as a golden standard procedure for skin tightening. Hifu is able to lead a potential coagulative necrosis indepth tissue without damaging peripheral vital anatomy structures. In the short term, high intensity focused ultrasound seems to have fewer side effects than other cancer treatments.
Evolution and outcomes of 3 mhz high intensity focused ultrasound therapy for localized prostate cancer during 15 years. The information on this page is based on literature searches and specialist checking. High intensity focused ultrasound hifu is an advanced technology which deploys focused, high energy, controlled ultrasound waves to heat and destroy the areas of the prostate gland affected by cancer. High intensity focused ultrasound hifu is a rapidly maturing technology with diverse clinical applications. Other ultrasound treatment methods include ultrasoundassisted drug delivery. This is also true for high intensity focused ultrasound, with each company bringing their take on the technology to the table it can be diffcult to separate marketing from real results.
High intensity focused ultrasound medical clinical. The feasibility of focused ultrasound for thermal therapy has been well established for more than 50 years. When propagated into human tissue, the pressure waves are either reflected or absorbed. While the process is not intended to boil an organ, more physicians are seeking out this method to heat up and denature the affected tissues. To evaluate the complications of highintensity focused ultrasound hifu in patients with hepatic and pancreatic cancer. High intensity focused ultrasound, or hifu, is a therapy option for prostate cancer patients where the tumor is still confined to the organ and has not spread to other areas of the body. High intensity focused ultrasound is a noninvasive procedure that is similar to focusing the sun on a leaf with a magnifying glass. Highintensity focused ultrasound of lesion, and the mdct finding was interpreted therapeutic procedure highintensity focused ultrasound ablation was performed with a system jc hifu, chongqing haifu technology equipped with an ultrasound device for realtime guidance of the treatment. It has long been known that highintensity focused ultrasound hifu can kill tissue through coagulative necrosis. Jan 17, 20 high intensity focused ultrasound hifu is a rapidly maturing technology with diverse clinical applications.
Hifuhigh intensity focused ultrasound ruixi aesthetic. High intensity focused ultrasound, or hifu, is a treatment that has only recently obtained fda approval in the united states. The focused beam causes localized high temperatures 55 to 90c in a region as small as 1 x 1 x 5 mm. Hifu is different from cryotherapy in that the focal zone is extremely discrete with little or no tissue effects in. Ce 1 introduction high intensity focused ultrasound hifu is a non invasive technique used for provoking thermal ablation within a target, i. An early history of highintensity focused ultrasound. The model jc tumour therapy device used in all treatments has previously been described by kennedy et al. The effect of the scanning pathway in highintensity focused. Ultrasound therapy, thermal ablation, cancer, heating, high intensity focused ultrasound hifu introduction the aim of most ablative therapies, whether for the treatment of cancer or of benign conditions, is the selective destruction of a targeted tissue volume, leaving surrounding tissues intact. Highintensity focused ultrasound radiology reference.
High intensity focused ultrasound hifu is a needleless, nonionizing, thermal ablation tool. High intensity focused ultrasound therapy korean j radiol 94, august 2008 293 fig. High intensity focused ultrasound on sales quality high. Ultrasound waves are acoustic pressure waves that have a frequency range that begins at the limit of human hearing, 20 khz, and extends well into the megahertz range. High intensity focused ultrasound hifu for fibroid uterus. Guttlers life in pictures 2012 example of a biopsy called class iii but was inadequate due to bloody distortion artifacts. Bill obrienis the director of the bioacoustics research. The earliest attempts at focused ultrasound therapy were simply targeted by using xrays or ultrasound. Ultrasound energy, or sound waves, is focused at a specific location and at that focal point, the temperature raises to almost 90 degrees celsius in a matter of seconds. A highintensity focused ultrasound hifu procedure is one of the newest ways to treat prostate cancer. From january 2006 to december 2008, 3 sessions of hifu treatment were performed in 114 consecutive patients with primary hepatic tumor n 57, hepatic metastasis n 22, and pancreatic cancer n 35 under general anesthesia. Two basic forms of thermal therapy for treatment of prostate cancer have been developed.
By using the combination of high intensity focused ultrasound hifu and imaging method, fus has the potential to ablate tumor lesions precisely. High intensity focused ultrasound hifu prostate cancer uk. Pdf highintensity focused ultrasound treatment for. Obrien jr and floyd dunn foresighted leadership, the gi bill, and research conducted in an unventilated steam tunnel all contributed to the development of a now ubiquitous medical tool. Ultrasound beams are focused on fibroid, and accumulative energy of the beam at a focal point increases. Highintensity focused ultrasound hifu for definitive treatment of prostate cancer. European radiology 2016 volume 26 number 11 pages 40474056. Electrophysiological study 6 months after epicor highintensity focused ultrasound atrial. First high intensity focused ultrasound system for. Highintensity focused ultrasound hifu or fus is a medical procedure that applies highintensity focused sonic energy to locally heat and destroy diseased or damaged tissue through ablation. Though it hasnt been approved for the treatment of prostate cancer in the u. You may hear your doctor call it noninvasive, which means a surgeon doesnt have to cut.
Ultrasound beams are focused on fibroid, and accumulative energy of the beam at a focal point increases the temperature over 65c and destroys the outgrowth. Unlike diagnostic ultrasound, hifu focuses the ultrasound waves precisely upon a target. Highintensity focused ultrasound treatment of liver tumours. This advancement in the treatment of prostate cancer is making it possible for patients with earlier stages of the disease to maintain their quality of life without. High intensity focused ultrasound other treatments cancer. A high intensity focused ultrasound hifu procedure is a technique approved by the fda to remove prostate tissue. Review clinical application of highintensity focused. Standard treatments are currently limited to chemotherapy, radiotherapy, or a combination of the two. All treatments were performed prone under general anaesthetic figure 1. A highintensity focused ultrasound hifu procedure is a technique approved by the fda to remove prostate tissue. Of these, mrghifu is not currently available in ontario. High intensity focused ultrasound hifu or fus is a medical procedure that applies high intensity focused sonic energy to locally heat and destroy diseased or damaged tissue through ablation. As seen in equation, intensity is proportional to square of acoustic pressure. High intensity focused ultrasound hifu has been successfully used as a novel hyperthermia therapy of tumors in clinical application.
Other ultrasound treatment methods include ultrasound assisted drug delivery. Pdf an introduction to high intensity focused ultrasound. Simultaneous treatment with marketleading devices harkermartinez, simon. Uchida t, nakano m, hongo s, shoji s, nagata y, satoh t, et al. Pdf ultrasound can penetrate deep into tissues and interact with human tissue via thermal and mechanical mechanisms. High intensity focused ultrasound hifs is the use of highfrequency sound waves focused on a tumour to generate extreme heat in that particular area, killing off the malicious cancer cells targeted without damaging the surrounding tissue. High intensity focused ultrasound procedure for prostate cancer. Hifu or high intensity focused ultrasound is a noninvasive, extremely precise procedure that uses ultrasound to heat and destroy uterine fibroid. Because of the this, it is not yet widely available in the u.
Hifu is a hyperthermia therapy that uses temperature to treat diseases. In the field of oncology, the use of hifu to noninvasively cause tissue necrosis in a defined target, a technique known as focused ultrasound surgery fus, has considerable potential for tumour ablation. A focused beam of sound waves is directed at cancer cells in order to heat them and destroy them. A high intensity focused ultrasound hifu procedure is one of the newest ways to treat prostate cancer. Highintensity focused ultrasound hifu is a new technique that can cause cell death and tissue necrosis by focusing high energy ultrasonic waves on a single location, and it has attracted recent interest as a noninvasive therapy particularly for cancer treatment. Clinical trials of highintensity focused ultrasound hifu began in the early 1990s in. Hifu pronounced hifoo, or high intensity focused ultrasound, is an exciting prostate cancer treatment technology that has revolutionized the treatment of prostate cancers. Hifu can be used to increase the flow of blood or lymph, or to destroy tissue, such as tumors, through a number of mechanisms. The technology can be used to treat a range of disorders and as of 2015 is at various stages of development and commercialization. It literally achieves the results of a facelift or a body lifts without any invasive surgery or injections, moreover. High intensity focused ultrasound hifu machine hifu. The target tumour was identified using the integrated diagnostic ultrasound transducer 3.
Its used to ablate prostate tissue in a noninvasive way, relying. In a similar way to how light can be focused to a burning point by a magnifying glass, ultrasound passes through the body without any effect but generating lethal heat 65 o c exactly where they are focused. High intensity focused ultrasound hifu is a noninvasive therapeutic technique that uses nonionizing ultrasonic waves to heat tissue. High intensity focused ultrasound hifu is gaining rapid clinical acceptance as a treatment modality enabling noninvasive tissue heating and ablation for. Focused ultrasound fus, also called high intensity focused ultrasound hifu, has gained a lot of interest in recent years as noninvasive cancer therapy that does not require radiation, chemotherapy, or surgery, resulting is less collateral damage to the patient. Highintensity focused ultrasound for the treatment of prostate.
Though few regimens may offer a limited survival benefit, novel treatment strategies are urgently needed. Highintensity focused ultrasound hifu is a noninvasive therapeutic technique that uses nonionizing ultrasonic waves to heat tissue. Garcia r, sacher f, oses p, derval n, barandon l, denis a, hocini m, roques x, haissaguerre m, labrousse l, jais p. High intensity focused ultrasound hifu is a minimally invasive, outpatient, and radiationfree procedure that patients can undergo in a few hours and return home the same day. High intensity focused ultrasound other treatments. To achieve this, high intensity focused ultrasound hifu waves are accurately coupled through the skin and aimed at the target volume, e. In principle, where surgery usually aims to remove a tumour with an adequate normaltissue margin, if a minimally invasive technique can destroy the equivalent tissue volume, then outcome in terms of diseasefree survival should be at least equal.
Highintensity focused ultrasound as focal therapy of prostate cancer. As a noninvasive approach, high intensity focused ultrasound therapy can selectively ablate a targeted lesion of the pancreas. Highintensity focused ultrasound hifu for pancreatic carcinoma. Studies have used high intensity focused ultrasound to ablate tissue in localised brain regions for movement disorders and chronic pain while sparing the overlying and. High intensity focused ultrasound hifu uses high frequency ultrasound energy to heat and destroy cancer cells in the prostate. Highintensity focused ultrasound ablation in hepatic and. High intensity focused ultrasound hifu for fibroid. Fus is performed as an outpatient procedure, so it can eliminate the usual two weeks of recovery needed from most types of surgery. High intensity focused ultrasound hifu directly delivers heat energy to skin and subcutaneous tissue that can stimulate and renew the skins collagen and thus consequently improving the texture and reducing sagging of the skin. Every 3second burst of the hifu beam heats the target tissue to 88. With the use of low temperature sensitive liposomes ltsls, high intensity.
Highintensity focused ultrasound therapy for prostate cancer. Focused ultrasound fus, also called highintensity focused ultrasound hifu, has gained a lot of interest in recent years as noninvasive cancer therapy that does not require radiation, chemotherapy, or surgery, resulting is less collateral damage to the patient. Focused ultrasound surgery fus is a noninvasive technique. High intensity focused ultrasound thyroid center of. High intensity focused ultrasound offers new tumor treatment. An early history of highintensity focused ultrasound william d. Highintensity focused ultrasound hifu therapy, also known as focused ultrasound surgery fus, is a noninvasive technology that delivers ultrasound us. However, it has yet to reach wide application in the clinic. The ability of ultrasound to be focused into a small region of interest through the intact skull within the brain has led researchers to investigate its potential therapeutic uses for functional neurosurgery and tumor ablation. Hifu prostate cancer treatment western states hifu. Prostate cancer prostate cancer, accounting for 33 % of all male cancers, is the 2nd leading cause of cancer death in men, exceeded only by lung cancer. Highintensity focused ultrasound is a rel atively new technique that has great poten tial for further development.
Relationships between sound pressure, power, energy, and intensity. The main reason for this has been the lack of a way to monitor procedures. Health quality ontario was asked to investigate the use of. High intensity focused ultrasound semantic scholar. In the short term, highintensity focused ultrasound seems to have fewer side effects than other cancer treatments. Pdf highintensity focused ultrasound attenuates neural. High intensity focused ultrasound, or hifu, is an fda approved therapy that destroys tissue with rapid heat elevation, which essentially cooks the tissue. Hifu application in the palliative treatment of pancreatic. By using the combination of highintensity focused ultrasound hifu and imaging method, fus has the potential to ablate tumor lesions.
Highintensity focused ultrasound is a method that focuses ultrasound to heatablate target tissues without injuring surrounding structures. An ultrasound probe focuses sound waves to an area as small as a grain of rice, similar to sunlight focused by a magnifying glass, elevating the tissue temperature to a point that the tissue cannot survive 70 to90 degrees. High intensity focused ultrasound hifu or hifus is a cancer treatment which uses sound waves at high frequency. Sonic intensity, defined as energy passing through unit area within unit time, is derived from plane wave. E16 february 2018 with 309 reads how we measure reads. Highintensity focused ultrasound hifu or hifus is a cancer treatment which uses sound waves at high frequency. In high intensity focused ultrasound hifu, a specially designed transducer is used to focus a beam of ultrasound energy into a small volume at specific target locations within the body.
Though potential clinical applications of hifu were reported as early. Studies have used highintensity focused ultrasound to ablate tissue in localised brain regions for movement disorders and chronic pain while sparing the overlying and. The technology can be used to treat a range of disorders and as of 2015 is at. To evaluate the complications of high intensity focused ultrasound hifu in patients with hepatic and pancreatic cancer. High intensity focused ultrasound hifu high intensity focused ultrasound hifu is a minimallyinvasive surgical technique for the thermal ablation of both malignant and benign tumors and cessation of internal bleeding in injured vessels and organs with little. In the focal area, tissue temperature increases rapidly, within seconds, up to 60 c or higher. A beam of ultrasound energy travels into the prostate from a probe put into the back passage rectum. Highintensity focused ultrasound in the treatment of. Hifu uses ultrasound waves to neutralize cancerous prostate cells instead of surgery or radiation which eliminates the need for an overnight hospital stay and incisions. Highintensity focused ultrasound in the treatment of solid. Highintensity focused ultrasound hifu is an emerging technology that has potential to use ultrasound energy directly for therapeutic purposes, including ablation and enhancing drug delivery.
1128 74 903 1001 866 834 1171 1095 520 238 1030 470 1043 571 1361 556 616 397 792 428 77 1103 1456 1117 1408 392 563 1536 1484 167 1103 820 588 1267 1438 1007 1475 1438 694 364 549 928 1291 211